ClinVar-BERT Prediction Lookup

Enter one or more search criteria below. Leave fields empty to ignore them.

Gene Symbol

Case-insensitive gene symbol

ClinVar VCV

ClinVar RCV

ClinVar SCV

ClinVar VariationID

Chromosome

Position (GRCh38)

Reference Allele

Alternate Allele

Search Results (click on Comment cell to see full text)

Gene: Gene symbol
Variant: Genomic coordinates (GRCh38) in format chr:pos ref>alt
AA Change: Amino acid change (e.g., H1860P)
Prediction: Model's predicted label (P/LP, VUS, or B/LB)
Model Prediction Probabilities: P/LP, VUS, and B/LB probabilities (displayed one per line)
Clinical Significance: ClinVar's clinical significance
Submission Classification: Original submission classification
Conflicting Submissions: True if this variant has conflicting classifications across submissions (some benign, some pathogenic)
ClinVar Identifiers: VCV, RCV, SCV
Comment: Submission comment/evidence - Click on cell to view full text

Results are limited to 100 entries per search.

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Gene Symbol	ClinVar VCV	ClinVar RCV	ClinVar SCV	ClinVar VariationID	Chromosome	Position (GRCh38)	Reference Allele	Alternate Allele

View overall statistics about the prediction dataset.

About This Tool

This web interface allows you to search and view ClinVarBERT model predictions for ClinVar variants.

Model: ClinVarBERT - A BERT-based model for variant pathogenicity prediction
Training: Fine-tuned on ClinVar variant submissions with clinical evidence text
Output: Classifies variants into three categories:
- P/LP: Pathogenic/Likely Pathogenic
- VUS: Variant of Uncertain Significance
- B/LB: Benign/Likely Benign